methylation support+

with Quatrefolic® methylfolate, riboflavin, vitamin B6, vitamin B12, and betaine

DESCRIPTION BENEFITS SUGGESTED USE WHAT'S IN IT

Over half of the U.S. population has an MTHFR gene variant that can impact their ability to metabolize essential B vitamins like folic acid into their fully active forms which are required for every cell of our body. methylation support+ is an ultra-potency complex that delivers methylated folate as part of a family of fully activated B vitamins (B2, 6, 9, and 12) plus betaine. This gene-focused solution promotes optimal methylation pathways that impact everything from our DNA and neurotransmitters to our heart, brain, energy production, and protein balance.*

  • Fully activated B vitamin + betaine complex
  • Supports MTHFR gene variant pathways*
  • Required for synthesis of DNA and RNA, red blood cells, and neurotransmitters*
  • Supports healthy homocysteine and SAM-e levels*
  • Aids cardiovascular, neurological, and detox systems*
  • Fully activated B vitamin + betaine complex
  • Supports MTHFR gene variant pathways*
  • Required for synthesis of DNA and RNA, red blood cells, and neurotransmitters*
  • Supports healthy homocysteine and SAM-e levels*
  • Aids cardiovascular, neurological, and detox systems*

Take 3 capsules daily with water or as directed by your health care practitioner. Keep out of reach of children.

QUATREFOLIC® METHYLFOLATE
Quatrefolic® methylfolate is the fully activated, glucosamine salt form of methylated folic acid (5-MTHF), for optimal absorption and utilization in the body. Folate is an essential water-soluble B vitamin (B9) that vitally supports our heart, brain, cellular energy, and synthesis of amino acids, DNA, RNA, and red blood cells. In its bioactive form, folic acid is clinically shown to support healthy homocysteine and SAM-e levels to drive optimal methylation in every cell.*

RIBOFLAVIN (VITAMIN B2)
Our riboflavin 5’-phosphate is the fully bioactive form of this essential water-soluble micronutrient. Riboflavin (vitamin B2) is a precursor for major coenzyme flavoproteins in the body, a required cofactor for the MTHFR enzyme, and thus, folate metabolism and methylation. In addition to antioxidant and immune functions, vitamin B2 is also required for the production of niacin, vitamin B6, red blood cells, and ATP energy from the foods we consume each day.*

VITAMIN B6 Our vitamin B6 is in the bioactive pyridoxal 5’-phosphate form. This vitamin is a cofactor for 100+ enzymes in our body, particularly those essential to amino acid synthesis, energy and neurotransmitter production, antioxidant and immune function, plus protein and folate metabolism (key to methylation). Vitamin B6 helps maintain healthy homocysteine levels via conversion to cysteine, which serves as a building block for collagen, keratin, and glutathione.*

VITAMIN B12 Our methylated vitamin B12 (methylcobalamin) is the bioactive form of this pivotal nutrient that is whole-body relevant. It’s required for cellular energy, plus the formation of DNA, red blood cells, neurons, neurotransmitters, and antibodies. B12 serves a complementary role with folate in the methionine cycle, as they are both essential cofactors for one-carbon metabolism, optimal homocysteine recycling to methionine, and methylation.*

BETAINE A methyl derivative of the amino acid glycine, betaine (i.e., trimethylglycine) is a critical bioactive for lipid and energy metabolism, plus osmoregulation. Betaine is most famous for being a major methyl donor in the body, as it ensures homocysteine's conversion to methionine. In fact, high-potency betaine has been clinically shown to support homocysteine reduction and methionine regeneration, ultimately driving methylation function and health.*

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+ Cancel subscriptions, anytime
+ Each bottle contains a 30-day supply
+ 30-day money back guarantee
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Inside methylation support+

We care deeply about where our ingredients come from. We partner only with suppliers whose practices emphasize quality, science, and responsibility.

Quatrefolic® methylfolate is the fully activated, glucosamine salt form of methylated folic acid (5-MTHF), for optimal absorption and utilization in the body. Folate is an essential water-soluble B vitamin (B9) that vitally supports our heart, brain, cellular energy, and synthesis of amino acids, DNA, RNA, and red blood cells. In its bioactive form, folic acid is clinically shown to support healthy homocysteine and SAM-e levels to drive optimal methylation in every cell.*

5,000 mcg DFE (3,000 mcg folic acid)

Our riboflavin 5’-phosphate is the fully bioactive form of this essential water-soluble micronutrient. Riboflavin (vitamin B2) is a precursor for major coenzyme flavoproteins in the body, a required cofactor for the MTHFR enzyme, and thus, folate metabolism and methylation. In addition to antioxidant and immune functions, vitamin B2 is also required for the production of niacin, vitamin B6, red blood cells, and ATP energy from the foods we consume each day.*

50 mg

Our vitamin B6 is in the bioactive pyridoxal 5’-phosphate form. This vitamin is a cofactor for 100+ enzymes in our body, particularly those essential to amino acid synthesis, energy and neurotransmitter production, antioxidant and immune function, plus protein and folate metabolism (key to methylation). Vitamin B6 helps maintain healthy homocysteine levels via conversion to cysteine, which serves as a building block for collagen, keratin, and glutathione.*

100 mg

Our methylated vitamin B12 (methylcobalamin) is the bioactive form of this pivotal nutrient that is whole-body relevant. It’s required for cellular energy, plus the formation of DNA, red blood cells, neurons, neurotransmitters, and antibodies. B12 serves a complementary role with folate in the methionine cycle, as they are both essential cofactors for one-carbon metabolism, optimal homocysteine recycling to methionine, and methylation.*

2,000 mcg

A methyl derivative of the amino acid glycine, betaine (i.e., trimethylglycine) is a critical bioactive for lipid and energy metabolism, plus osmoregulation. Betaine is most famous for being a major methyl donor in the body, as it ensures homocysteine's conversion to methionine. In fact, high-potency betaine has been clinically shown to support homocysteine reduction and methionine regeneration, ultimately driving methylation function and health.*

1,700 mg

What we leave out is just as important as what we add in

GMO-free
No binders, preservatives, coatings, shellacs, gums, carrageenan or magnesium stearate
No gluten, eggs, dairy, peanuts, tree nuts, fish, shellfish or soy
No artificial colors or flavors, no MSG
Low or no FODMAPs, low or no lectins
No artificial sweeteners, HFCS or stevia

Got Questions?

Toggle Answer

How should I take methylation support+?

Take 3 capsules daily with water or as recommended by your healthcare practitioner. Store tightly sealed in a cool, dry place without direct sunlight. If you are pregnant or breastfeeding or planning to become pregnant, out of an abundance of caution, we recommend consulting your health care practitioner before using methylation support+ or any dietary supplement product. Keep out of reach of children.

Toggle Answer

At what time of day should I take methylation support+?

You can take methylation support+ at any point in the day with or without food. Some customers choose to leverage this comprehensive methylation support first thing in the morning, while others incorporate it into their afternoon or evening. Some customers may find B vitamins to be energizing, so many people opt to take methylation support+ in the morning or midday instead of near bedtime. Since methylation is a 24/7 whole-body process in all of your cells, the more important aspect of timing is daily consistency.*

Toggle Answer

Why would I consider or need a targeted supplement to support methylation?

Methylation is an essential, whole-body biochemical process that is unfortunately overlooked by many. Methylation happens billions of times per second in the cells of our body, and proper methylation is critical for major physiological functions such as cardiovascular, neurological, detoxification systems, epigenetics, and more. The process of methylation is complex and relies on a daily network of nutrients in their bioactive forms and functional enzymes to keep it chugging along. Sufficiency of these nutrients support various enzymes and phases of the cycles that drive methylation.


There are a number of factors that can interfere with optimal methylation processes. Some of these factors include diet, lifestyle habits, and individual makeup (genetic variants influencing those for the MTHFR gene). These factors, especially individual responses due to our unique genetic makeup, can contribute to suboptimal methylation. mbg’s methylation support+ is a specialized bioactive B complex featuring the active forms of folate (methylfolate, 5-MTHF), vitamin B12, vitamin B6, and riboflavin (vitamin B2), and betaine. Whether you have an MTHFR gene variant or not, this targeted complex is designed to optimize absorption and utilization of these methylation essentials for overall health.*

Toggle Answer

What is methylation?

Methylation, in simple terms, refers to the transfer of methyl groups (one carbon and three hydrogen molecules (CH3)) from one substance or compound to another in the body. Various biological compounds throughout our body require methylation in order to function properly, including supporting the production and maintenance of amino acids, neurotransmitters, hormones, and much more. Methylation affects nearly all physiological processes, on a cellular and systemic level, even regulating activity of cardiovascular, neurological, and detoxification systems.


Methyl groups are provided by a variety of micronutrients and compounds, collectively known as “methyl donors”. These include essential B vitamins (folate (B9), vitamin B12, vitamin B6, riboflavin (B2)) and betaine, especially in their most bioactive forms. These are star players in supporting optimal methylation, as they directly support various steps in interlinking metabolic pathways that drive methylation processes, including the folate and methionine cycles.


The folate cycle is critical for feeding the active form of folate (5-MTHF), one of the most important methyl donors, into the methionine cycle. Folic acid (from certain supplements and fortified foods) and folate (from dietary sources) require multiple steps of conversion, relying on proper functioning of enzymes to arrive at its fully active form. One of these is the MTHFR enzyme, for which over half the U.S. population has a gene variant impacting its efficiency. Active folate is required for the proper metabolism and conversion of homocysteine, (plus the help of other important methyl donors such as vitamin B12 and betaine) into methionine.


Methionine, an essential amino acid important for the production of various proteins throughout the body (everything from muscles and antibodies, to hormones), is also required for the synthesis of SAM-e, the body’s universal methyl donor. SAM-e, with the help of specialized enzymes called methyltransferases, supports all methylation processes in the body. Once SAM-e donates its methyl groups, it is converted back into homocysteine to feed back into the cycle. These cycles with their supportive nutrients in their bioactive forms drive methylation. mbg’s methylation support+ is focused, precision nutrition solution for whole-body methylation health and function.*

Toggle Answer

What's the MTHFR gene?

The MTHFR gene provides necessary instructions in the body to make the MTHFR enzyme, methylenetetrahydrofolate reductase. This enzyme is vitally important for the conversion of folate (from leafy greens, legumes, etc.) and folic acid (from certain supplements and fortified foods), into its fully active, methylated form 5-methyltetrahydrofolate (5-MTHF). This bioactive form of folate is critically important for the methylation functions described above.


There can be a lot of variation in individuals’ ability to efficiently convert folic acid into its bioactive form (5-MTHF) due to our unique individual make-up (genetic patterns and expressions). An MTHFR gene variant or single nucleotide polymorphism (SNP), in simple terms, is a deviation in the MTHFR gene. These variants can significantly impact the body’s ability to optimally process and metabolize folate, thus impacting the globally essential biochemical process of methylation.


methylation support+ is mbg’s first nutrigenomics-inspired supplement that is a gene-focused solution for MTHFR gene variants and whole-body methylation health and function. While everyone can benefit from the formula, it represents a focused, precision nutrition solution for those with MTHFR gene variants (i.e., estimated to be more than half the U.S.). With methylation support+, we can fully leverage the many essential processes that methylation impacts in our body (heart, brain, detox, energy, etc.)!*

Toggle Answer

Can I take methylation support+ with other mindbodygreen supplements?

Yes. At mindbodygreen, you'll find many complementary combinations to support your health to be the best version of you. This methylation-focused product can be combined with any mbg supplement. If you have specific health considerations related to high-potency B complexes, we recommend consulting your health care practitioner before using methylation support+ or any dietary supplement product.*

Toggle Answer

Does mindbodygreen offer a refillable program?

Our high-quality formulas are delivered in premium, sustainable, and recyclable packaging (recyclable amber glass bottles and jars, recyclable bags, and recyclable cardboard shipping boxes made from 100% recycled paper). Always looking towards the latest innovations, we carefully and intentionally source our eco-friendly packaging to prioritize the environment, but also to protect the premium ingredients in our capsules, gelcaps, and powders (i.e., vitamins, minerals, botanicals, peptides, probiotics, bioactives) from UV light degradation. This is pivotal to ensure quality standards throughout the lifecycle of the product.


Unfortunately many refillable bags or containers do not provide the same protection and stability for our ingredients as our amber glass (bottles, jars) and PET bags achieve. What's more, the product-specific manufacturing information (i.e., specific identifiers such as the lot and date) stamped on each product would be lost when the customer discards the refill packaging, as is customary. That lost information would not enable us to comply with a variety of very important FDA regulations specific to dietary supplements (e.g., cGMPs, adverse event reporting, etc.), and regulatory compliance is something that mindbodygreen respects and prioritizes. From an additional safety standpoint, there are also microbial contamination concerns with refillable vessels over time. Thank you for your consideration as to why we have thoughtfully curated our packaging in the way we do.

Toggle Answer

Is methylation support+ vegan?

Yes. This vegan product is also GMO-free, gluten-free, soy-free, dairy-free, and major food allergen free.

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4 Rounds of testing

Our products go through 4 rounds of testing at Thorne’s state-of-the-art labs. Most competitors test only once or twice.

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Our products are tested for potency, purity, and contaminants like heavy metals and pesticides in an ISO-certified lab.

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None of our products contain artificial coloring or sweeteners, or unnecessary stearates or preservatives.

Supports cardiovascular health with ultra potent B vitamin complex*

methylation support+

DESCRIPTION BENEFITS SUGGESTED USE WHAT'S IN IT

with Quatrefolic® methylfolate, riboflavin, vitamin B6, vitamin B12, and betaine

Over half of the U.S. population has an MTHFR gene variant that can impact their ability to metabolize essential B vitamins like folic acid into their fully active forms which are required for every cell of our body. methylation support+ is an ultra-potency complex that delivers methylated folate as part of a family of fully activated B vitamins (B2, 6, 9, and 12) plus betaine. This gene-focused solution promotes optimal methylation pathways that impact everything from our DNA and neurotransmitters to our heart, brain, energy production, and protein balance.*

  • Fully activated B vitamin + betaine complex
  • Supports MTHFR gene variant pathways*
  • Required for synthesis of DNA and RNA, red blood cells, and neurotransmitters*
  • Supports healthy homocysteine and SAM-e levels*
  • Aids cardiovascular, neurological, and detox systems*
Read More

Over half of the U.S. population has an MTHFR gene variant that can impact their ability to metabolize essential B vitamins like folic acid into their fully active forms which are required for every cell of our body. methylation support+ is an ultra-potency complex that delivers methylated folate as part of a family of fully activated B vitamins (B2, 6, 9, and 12) plus betaine. This gene-focused solution promotes optimal methylation pathways that impact everything from our DNA and neurotransmitters to our heart, brain, energy production, and protein balance.*

  • Fully activated B vitamin + betaine complex
  • Supports MTHFR gene variant pathways*
  • Required for synthesis of DNA and RNA, red blood cells, and neurotransmitters*
  • Supports healthy homocysteine and SAM-e levels*
  • Aids cardiovascular, neurological, and detox systems*
  • Fully activated B vitamin + betaine complex
  • Supports MTHFR gene variant pathways*
  • Required for synthesis of DNA and RNA, red blood cells, and neurotransmitters*
  • Supports healthy homocysteine and SAM-e levels*
  • Aids cardiovascular, neurological, and detox systems*

Take 3 capsules daily with water or as directed by your health care practitioner. Keep out of reach of children.

QUATREFOLIC® METHYLFOLATE
Quatrefolic® methylfolate is the fully activated, glucosamine salt form of methylated folic acid (5-MTHF), for optimal absorption and utilization in the body. Folate is an essential water-soluble B vitamin (B9) that vitally supports our heart, brain, cellular energy, and synthesis of amino acids, DNA, RNA, and red blood cells. In its bioactive form, folic acid is clinically shown to support healthy homocysteine and SAM-e levels to drive optimal methylation in every cell.*

RIBOFLAVIN (VITAMIN B2)
Our riboflavin 5’-phosphate is the fully bioactive form of this essential water-soluble micronutrient. Riboflavin (vitamin B2) is a precursor for major coenzyme flavoproteins in the body, a required cofactor for the MTHFR enzyme, and thus, folate metabolism and methylation. In addition to antioxidant and immune functions, vitamin B2 is also required for the production of niacin, vitamin B6, red blood cells, and ATP energy from the foods we consume each day.*

VITAMIN B6 Our vitamin B6 is in the bioactive pyridoxal 5’-phosphate form. This vitamin is a cofactor for 100+ enzymes in our body, particularly those essential to amino acid synthesis, energy and neurotransmitter production, antioxidant and immune function, plus protein and folate metabolism (key to methylation). Vitamin B6 helps maintain healthy homocysteine levels via conversion to cysteine, which serves as a building block for collagen, keratin, and glutathione.*

VITAMIN B12 Our methylated vitamin B12 (methylcobalamin) is the bioactive form of this pivotal nutrient that is whole-body relevant. It’s required for cellular energy, plus the formation of DNA, red blood cells, neurons, neurotransmitters, and antibodies. B12 serves a complementary role with folate in the methionine cycle, as they are both essential cofactors for one-carbon metabolism, optimal homocysteine recycling to methionine, and methylation.*

BETAINE A methyl derivative of the amino acid glycine, betaine (i.e., trimethylglycine) is a critical bioactive for lipid and energy metabolism, plus osmoregulation. Betaine is most famous for being a major methyl donor in the body, as it ensures homocysteine's conversion to methionine. In fact, high-potency betaine has been clinically shown to support homocysteine reduction and methionine regeneration, ultimately driving methylation function and health.*

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  • Each bottle contains a 30-day supply
  • 30-day money back guarantee
  • Formulated, manufactured, and packaged in the USA
Good To Know
  • GMO-free
  • major food allergen free
  • gluten-free
  • dairy-free
  • soy-free
  • vegan
Good To Know
  • GMO-free
  • major food allergen free
  • gluten-free
  • dairy-free
  • soy-free
  • vegan

MAXIMIZE WHOLE-BODY HEALTH vitamin C potency+

A potent antioxidant that helps your body run properly every single day—not just certain times of the year.*

MAXIMIZE WHOLE-BODY HEALTH vitamin C potency+

A potent antioxidant that helps your body run properly every single day—not just certain times of the year.*

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$32  ADD  |  $27  SUBSCRIBE

Our methylation support+ formula

We care deeply about where our ingredients come from. We partner only with suppliers whose practices emphasize quality, science, and responsibility.

Quatrefolic® methylfolate is the fully activated, glucosamine salt form of methylated folic acid (5-MTHF), for optimal absorption and utilization in the body. Folate is an essential water-soluble B vitamin (B9) that vitally supports our heart, brain, cellular energy, and synthesis of amino acids, DNA, RNA, and red blood cells. In its bioactive form, folic acid is clinically shown to support healthy homocysteine and SAM-e levels to drive optimal methylation in every cell.*

5,000 mcg DFE (3,000 mcg folic acid)

Our riboflavin 5’-phosphate is the fully bioactive form of this essential water-soluble micronutrient. Riboflavin (vitamin B2) is a precursor for major coenzyme flavoproteins in the body, a required cofactor for the MTHFR enzyme, and thus, folate metabolism and methylation. In addition to antioxidant and immune functions, vitamin B2 is also required for the production of niacin, vitamin B6, red blood cells, and ATP energy from the foods we consume each day.*

50 mg

Our vitamin B6 is in the bioactive pyridoxal 5’-phosphate form. This vitamin is a cofactor for 100+ enzymes in our body, particularly those essential to amino acid synthesis, energy and neurotransmitter production, antioxidant and immune function, plus protein and folate metabolism (key to methylation). Vitamin B6 helps maintain healthy homocysteine levels via conversion to cysteine, which serves as a building block for collagen, keratin, and glutathione.*

100 mg

Our methylated vitamin B12 (methylcobalamin) is the bioactive form of this pivotal nutrient that is whole-body relevant. It’s required for cellular energy, plus the formation of DNA, red blood cells, neurons, neurotransmitters, and antibodies. B12 serves a complementary role with folate in the methionine cycle, as they are both essential cofactors for one-carbon metabolism, optimal homocysteine recycling to methionine, and methylation.*

2,000 mcg

A methyl derivative of the amino acid glycine, betaine (i.e., trimethylglycine) is a critical bioactive for lipid and energy metabolism, plus osmoregulation. Betaine is most famous for being a major methyl donor in the body, as it ensures homocysteine's conversion to methionine. In fact, high-potency betaine has been clinically shown to support homocysteine reduction and methionine regeneration, ultimately driving methylation function and health.*

1,700 mg

Setting higher quality standards

GMO-free
No binders, preservatives, coatings, shellacs, gums, carrageenan or magnesium stearate
No gluten, eggs, dairy, peanuts, tree nuts, fish, shellfish or soy
No artificial colors or flavors, no MSG
Low or no FODMAPs, low or no lectins
No artificial sweeteners, HFCS or stevia
AS SEEN IN
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Reviewed by a team of experts

Methylation is the biggest silent issue when it comes to our health and longevity.

Jason Wachob
mbg Founder & Co-CEO

This is the complex I recommend for daily methylation support because it's optimized for bioactivity and efficacy.*

Madiha Saeed, M.D.
Family Medicine Physician

Methylation is the biggest silent issue when it comes to our health and longevity.

Jason Wachob
mbg Founder & Co-CEO

Methylfolate—a critical nutrient to support individuals with MTHFR gene variants*

Whitney Crouch, R.D.N., C.L.T.
Integrative Registered Dietitian

There are a number of different forms of vitamin B9, but only one—methylfolate—is biologically active.

Silvia Pisoni, Ph.D.
Reproduction and Women’s Health Global Manager, Gnosis by Lesaffre

Reviewed by a team of experts

This is the complex I recommend for daily methylation support because it's optimized for bioactivity and efficacy.*

Madiha Saeed, M.D.

As a physician who practices a holistic approach to health, unique genetic differences and optimizing methylation are top of mind for me and directly impact how I care for my clients. The MTHFR gene variant is extremely common in the U.S. and globally, yet ignored by most. mbg's methylation support+ is thankfully changing that conversation. From cellular health, to cardio- and neuroprotective benefits, and even epigenetic power, this specialized bioactive B complex is the complex I recommend for daily methylation support because it's optimized for bioactivity and efficacy.*

Methylation is the biggest silent issue when it comes to our health and longevity.

Jason Wachob

Cardiovascular issues run in my family, so I wanted to get more sophisticated around health testing in my 40's. Since I felt fine, I was shocked to discover I had suboptimal methylation and the MTHFR gene variant. Within months of targeted supplementation with a specific array of bioactive B vitamins and betaine, my methylation function and homocysteine levels were stellar. I believe methylation is the biggest silent issue when it comes to our health and longevity. It feels like this formula saved my life, and I'm beyond grateful that I'm here to tell this story to bring you the product I am most proud of, methylation support+.*

Methylfolate—a critical nutrient to support individuals with MTHFR gene variants*

Whitney Crouch, R.D.N., C.L.T.

As an integrative dietitian supporting women with complex metabolic needs, the world of genetics and bio-individuality directly informs personalized care plans. It makes sense to address issues unique to one's own genes and biochemistry. I love that mbg's methylation support+ smartly combines active methylfolate—a critical nutrient to support individuals with MTHFR gene variants—plus other essential cofactors for methylation and whole-body pathways. Combining these nutrients into one daily product makes it easy to stick to and experience health improvements!*

There are a number of different forms of vitamin B9, but only one—methylfolate—is biologically active.

Silvia Pisoni, Ph.D.

As an expert in folate, I want to focalize a term that we hear often in the conversation around nutrition, and that is "bioactive". To explain the importance of bioactivity, vitamin B9 (aka folate) is a perfect example. There are a number of different forms of vitamin B9, but only one—methylfolate—is biologically active. The other forms have to be converted into the active one. mbg's methylation support+ takes full advantage of this scientific fact by providing Quatrefolic® methylfolate, leading the targeted formula for methylation and health.*

How does methylation support+ compare to others?

Reviews

Customer Reviews

Frequently Asked Questions

Toggle Answer

How should I take methylation support+?

Take 3 capsules daily with water or as recommended by your healthcare practitioner. Store tightly sealed in a cool, dry place without direct sunlight. If you are pregnant or breastfeeding or planning to become pregnant, out of an abundance of caution, we recommend consulting your health care practitioner before using methylation support+ or any dietary supplement product. Keep out of reach of children.

Toggle Answer

At what time of day should I take methylation support+?

You can take methylation support+ at any point in the day with or without food. Some customers choose to leverage this comprehensive methylation support first thing in the morning, while others incorporate it into their afternoon or evening. Some customers may find B vitamins to be energizing, so many people opt to take methylation support+ in the morning or midday instead of near bedtime. Since methylation is a 24/7 whole-body process in all of your cells, the more important aspect of timing is daily consistency.*

Toggle Answer

Why would I consider or need a targeted supplement to support methylation?

Methylation is an essential, whole-body biochemical process that is unfortunately overlooked by many. Methylation happens billions of times per second in the cells of our body, and proper methylation is critical for major physiological functions such as cardiovascular, neurological, detoxification systems, epigenetics, and more. The process of methylation is complex and relies on a daily network of nutrients in their bioactive forms and functional enzymes to keep it chugging along. Sufficiency of these nutrients support various enzymes and phases of the cycles that drive methylation.


There are a number of factors that can interfere with optimal methylation processes. Some of these factors include diet, lifestyle habits, and individual makeup (genetic variants influencing those for the MTHFR gene). These factors, especially individual responses due to our unique genetic makeup, can contribute to suboptimal methylation. mbg’s methylation support+ is a specialized bioactive B complex featuring the active forms of folate (methylfolate, 5-MTHF), vitamin B12, vitamin B6, and riboflavin (vitamin B2), and betaine. Whether you have an MTHFR gene variant or not, this targeted complex is designed to optimize absorption and utilization of these methylation essentials for overall health.*

Toggle Answer

What is methylation?

Methylation, in simple terms, refers to the transfer of methyl groups (one carbon and three hydrogen molecules (CH3)) from one substance or compound to another in the body. Various biological compounds throughout our body require methylation in order to function properly, including supporting the production and maintenance of amino acids, neurotransmitters, hormones, and much more. Methylation affects nearly all physiological processes, on a cellular and systemic level, even regulating activity of cardiovascular, neurological, and detoxification systems.


Methyl groups are provided by a variety of micronutrients and compounds, collectively known as “methyl donors”. These include essential B vitamins (folate (B9), vitamin B12, vitamin B6, riboflavin (B2)) and betaine, especially in their most bioactive forms. These are star players in supporting optimal methylation, as they directly support various steps in interlinking metabolic pathways that drive methylation processes, including the folate and methionine cycles.


The folate cycle is critical for feeding the active form of folate (5-MTHF), one of the most important methyl donors, into the methionine cycle. Folic acid (from certain supplements and fortified foods) and folate (from dietary sources) require multiple steps of conversion, relying on proper functioning of enzymes to arrive at its fully active form. One of these is the MTHFR enzyme, for which over half the U.S. population has a gene variant impacting its efficiency. Active folate is required for the proper metabolism and conversion of homocysteine, (plus the help of other important methyl donors such as vitamin B12 and betaine) into methionine.


Methionine, an essential amino acid important for the production of various proteins throughout the body (everything from muscles and antibodies, to hormones), is also required for the synthesis of SAM-e, the body’s universal methyl donor. SAM-e, with the help of specialized enzymes called methyltransferases, supports all methylation processes in the body. Once SAM-e donates its methyl groups, it is converted back into homocysteine to feed back into the cycle. These cycles with their supportive nutrients in their bioactive forms drive methylation. mbg’s methylation support+ is focused, precision nutrition solution for whole-body methylation health and function.*

Toggle Answer

What's the MTHFR gene?

The MTHFR gene provides necessary instructions in the body to make the MTHFR enzyme, methylenetetrahydrofolate reductase. This enzyme is vitally important for the conversion of folate (from leafy greens, legumes, etc.) and folic acid (from certain supplements and fortified foods), into its fully active, methylated form 5-methyltetrahydrofolate (5-MTHF). This bioactive form of folate is critically important for the methylation functions described above.


There can be a lot of variation in individuals’ ability to efficiently convert folic acid into its bioactive form (5-MTHF) due to our unique individual make-up (genetic patterns and expressions). An MTHFR gene variant or single nucleotide polymorphism (SNP), in simple terms, is a deviation in the MTHFR gene. These variants can significantly impact the body’s ability to optimally process and metabolize folate, thus impacting the globally essential biochemical process of methylation.


methylation support+ is mbg’s first nutrigenomics-inspired supplement that is a gene-focused solution for MTHFR gene variants and whole-body methylation health and function. While everyone can benefit from the formula, it represents a focused, precision nutrition solution for those with MTHFR gene variants (i.e., estimated to be more than half the U.S.). With methylation support+, we can fully leverage the many essential processes that methylation impacts in our body (heart, brain, detox, energy, etc.)!*

Toggle Answer

Can I take methylation support+ with other mindbodygreen supplements?

Yes. At mindbodygreen, you'll find many complementary combinations to support your health to be the best version of you. This methylation-focused product can be combined with any mbg supplement. If you have specific health considerations related to high-potency B complexes, we recommend consulting your health care practitioner before using methylation support+ or any dietary supplement product.*

Toggle Answer

Does mindbodygreen offer a refillable program?

Our high-quality formulas are delivered in premium, sustainable, and recyclable packaging (recyclable amber glass bottles and jars, recyclable bags, and recyclable cardboard shipping boxes made from 100% recycled paper). Always looking towards the latest innovations, we carefully and intentionally source our eco-friendly packaging to prioritize the environment, but also to protect the premium ingredients in our capsules, gelcaps, and powders (i.e., vitamins, minerals, botanicals, peptides, probiotics, bioactives) from UV light degradation. This is pivotal to ensure quality standards throughout the lifecycle of the product.


Unfortunately many refillable bags or containers do not provide the same protection and stability for our ingredients as our amber glass (bottles, jars) and PET bags achieve. What's more, the product-specific manufacturing information (i.e., specific identifiers such as the lot and date) stamped on each product would be lost when the customer discards the refill packaging, as is customary. That lost information would not enable us to comply with a variety of very important FDA regulations specific to dietary supplements (e.g., cGMPs, adverse event reporting, etc.), and regulatory compliance is something that mindbodygreen respects and prioritizes. From an additional safety standpoint, there are also microbial contamination concerns with refillable vessels over time. Thank you for your consideration as to why we have thoughtfully curated our packaging in the way we do.

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Is methylation support+ vegan?

Yes. This vegan product is also GMO-free, gluten-free, soy-free, dairy-free, and major food allergen free.

Safety & Quality: Testing Standards

4 rounds of Testing

Our products go through 4 rounds of advanced analytical testing at state-of-the-art labs. Many competitors test only once or twice.

Certified Labs

Our products are tested for precision, potency, and purity, including contaminants like microbes, heavy metals, and pesticides in ISO-certified labs.

Pure Ingredients

None of our products contain artificial coloring or sweeteners, or unnecessary stearates or preservatives.

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products

⭐️ shop holiday ⭐️

Holiday
Keep your well-being top of mind. Gifts, backed by science, for a better you+

gut health collection

gut health
Support regularity, bloating, gas and digestion

daily essentials collection

Daily Essentials
Well-being essentials to help you stay on top of your health*

longevity & vitality collection

longevity
Comprehensive longevity essentials for healthy aging*

sleep support+

Sleep
Finally, a supplement that delivers deep sleep - without any morning grogginess*

beauty & gut collagen+

beauty
The one-step beauty routine for holistic inside-out support.*

metabolism+

metabolic health
Multi-pronged approach to promote healthy weight & body composition*

organic fiber potency+

gut health
Advanced fiber sources to promote satiety and regularity*

eye health+

Longevity
Visual performance support for the digital age*

vitamin D3 potency+

daily essentials
Optimized vitamin D3 with absorption technology for whole-body health*

brain guard+

Nootropic
Brain nutrition for cognitive performance and mental clarity*

ultimate multivitamin+

daily essentials
Daily comprehensive multi that provides your body with a steady supply of the nutrients it needs to function at its best*

dream mist

nighttime linen mist
A turn-down service for your senses

turmeric potency+

Daily Essentials
Promotes a healthy inflammatory response for whole-body health*

postbiotic body lotion

microbiome skin care
Ultra-hydrating formula that nourishes your skin barrier

probiotic+

gut health
Four targeted strains to beat bloating and support gut health*

vitamin C potency+

Daily Essentials
A potent antioxidant that helps your body run properly every single day— not just certain times of the year.*

gut health bundle+

Gut Health
Reset your gut microbiome and optimize digestive health through the power of pre- and probiotics*

focus+

Nootropic
Sustained daily energy and focus, minus the crash*

omega-3 potency+

daily essentials
Delivers the right amount of crucial fatty acids so your body can function at its best.*

methylation support+

Daily essentials
Supports cardiovascular health with ultra potent B vitamin complex*

organic veggies+

daily greens
Nutritional power of daily greens made easy*

cellular beauty+

beauty
A revolutionary, science-backed cosmeceutical*

daily detox+

detoxification
Detox support to promote liver and whole-body cleanup*

immune support+

immunity
Your daily immunity shield*

glow from the inside out bundle+

beauty
Go deep beyond the surface with cellular beauty+ and beauty & gut collagen+

postbiotic hand cream

microbiome skin care
Rich yet fast-absorbing formula that nourish your microbiome

lip balm

microbiome skin care
Moringa-based formula which feeds your skin antioxidants, instantly hydrates, and protects your lips

practice self-care collection

Treat yourself
Promote a healthy glow, inside & out*

nootropics

Nootropics
Support executive function and cognitive flexibility*

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