Take 3 capsules daily with water or as recommended by your healthcare practitioner. Store tightly sealed in a cool, dry place without direct sunlight. If you are pregnant or breastfeeding or planning to become pregnant, out of an abundance of caution, we recommend consulting your health care practitioner before using methylation support+ or any dietary supplement product. Keep out of reach of children.

You can take methylation support+ at any point in the day with or without food. Some customers choose to leverage this comprehensive methylation support first thing in the morning, while others incorporate it into their afternoon or evening. Some customers may find B vitamins to be energizing, so many people opt to take methylation support+ in the morning or midday instead of near bedtime. Since methylation is a 24/7 whole-body process in all of your cells, the more important aspect of timing is daily consistency.*

Methylation is an essential, whole-body biochemical process that is unfortunately overlooked by many. Methylation happens billions of times per second in the cells of our body, and proper methylation is critical for major physiological functions such as cardiovascular, neurological, detoxification systems, epigenetics, and more. The process of methylation is complex and relies on a daily network of nutrients in their bioactive forms and functional enzymes to keep it chugging along. Sufficiency of these nutrients support various enzymes and phases of the cycles that drive methylation.

There are a number of factors that can interfere with optimal methylation processes. Some of these factors include diet, lifestyle habits, and individual makeup (genetic variants influencing those for the MTHFR gene). These factors, especially individual responses due to our unique genetic makeup, can contribute to suboptimal methylation. mbg’s methylation support+ is a specialized bioactive B complex featuring the active forms of folate (methylfolate, 5-MTHF), vitamin B12, vitamin B6, and riboflavin (vitamin B2), and betaine. Whether you have an MTHFR gene variant or not, this targeted complex is designed to optimize absorption and utilization of these methylation essentials for overall health.*

Methylation, in simple terms, refers to the transfer of methyl groups (one carbon and three hydrogen molecules (CH3)) from one substance or compound to another in the body. Various biological compounds throughout our body require methylation in order to function properly, including supporting the production and maintenance of amino acids, neurotransmitters, hormones, and much more. Methylation affects nearly all physiological processes, on a cellular and systemic level, even regulating activity of cardiovascular, neurological, and detoxification systems.

Methyl groups are provided by a variety of micronutrients and compounds, collectively known as “methyl donors”. These include essential B vitamins (folate (B9), vitamin B12, vitamin B6, riboflavin (B2)) and betaine, especially in their most bioactive forms. These are star players in supporting optimal methylation, as they directly support various steps in interlinking metabolic pathways that drive methylation processes, including the folate and methionine cycles.

The folate cycle is critical for feeding the active form of folate (5-MTHF), one of the most important methyl donors, into the methionine cycle. Folic acid (from certain supplements and fortified foods) and folate (from dietary sources) require multiple steps of conversion, relying on proper functioning of enzymes to arrive at its fully active form. One of these is the MTHFR enzyme, for which over half the U.S. population has a gene variant impacting its efficiency. Active folate is required for the proper metabolism and conversion of homocysteine, (plus the help of other important methyl donors such as vitamin B12 and betaine) into methionine.

Methionine, an essential amino acid important for the production of various proteins throughout the body (everything from muscles and antibodies, to hormones), is also required for the synthesis of SAM-e, the body’s universal methyl donor. SAM-e, with the help of specialized enzymes called methyltransferases, supports all methylation processes in the body. Once SAM-e donates its methyl groups, it is converted back into homocysteine to feed back into the cycle. These cycles with their supportive nutrients in their bioactive forms drive methylation. mbg’s methylation support+ is focused, precision nutrition solution for whole-body methylation health and function.*

The MTHFR gene provides necessary instructions in the body to make the MTHFR enzyme, methylenetetrahydrofolate reductase. This enzyme is vitally important for the conversion of folate (from leafy greens, legumes, etc.) and folic acid (from certain supplements and fortified foods), into its fully active, methylated form 5-methyltetrahydrofolate (5-MTHF). This bioactive form of folate is critically important for the methylation functions described above.

There can be a lot of variation in individuals’ ability to efficiently convert folic acid into its bioactive form (5-MTHF) due to our unique individual make-up (genetic patterns and expressions). An MTHFR gene variant or single nucleotide polymorphism (SNP), in simple terms, is a deviation in the MTHFR gene. These variants can significantly impact the body’s ability to optimally process and metabolize folate, thus impacting the globally essential biochemical process of methylation.

methylation support+ is mbg’s first nutrigenomics-inspired supplement that is a gene-focused solution for MTHFR gene variants and whole-body methylation health and function. While everyone can benefit from the formula, it represents a focused, precision nutrition solution for those with MTHFR gene variants (i.e., estimated to be more than half the U.S.). With methylation support+, we can fully leverage the many essential processes that methylation impacts in our body (heart, brain, detox, energy, etc.)!*

Yes. At mindbodygreen, you'll find many complementary combinations to support your health to be the best version of you. This methylation-focused product can be combined with any mbg supplement. If you have specific health considerations related to high-potency B complexes, we recommend consulting your health care practitioner before using methylation support+ or any dietary supplement product.*

Our high-quality formulas are delivered in premium, sustainable, and recyclable packaging (recyclable amber glass bottles and jars, recyclable bags, and recyclable cardboard shipping boxes made from 100% recycled paper). Always looking towards the latest innovations, we carefully and intentionally source our eco-friendly packaging to prioritize the environment, but also to protect the premium ingredients in our capsules, gelcaps, and powders (i.e., vitamins, minerals, botanicals, peptides, probiotics, bioactives) from UV light degradation. This is pivotal to ensure quality standards throughout the lifecycle of the product.

Unfortunately many refillable bags or containers do not provide the same protection and stability for our ingredients as our amber glass (bottles, jars) and PET bags achieve. What's more, the product-specific manufacturing information (i.e., specific identifiers such as the lot and date) stamped on each product would be lost when the customer discards the refill packaging, as is customary. That lost information would not enable us to comply with a variety of very important FDA regulations specific to dietary supplements (e.g., cGMPs, adverse event reporting, etc.), and regulatory compliance is something that mindbodygreen respects and prioritizes. From an additional safety standpoint, there are also microbial contamination concerns with refillable vessels over time. Thank you for your consideration as to why we have thoughtfully curated our packaging in the way we do.

Yes. This vegan product is also GMO-free, gluten-free, soy-free, dairy-free, and major food allergen free.